Frequently Asked Questions
Together they provide necessary information about mycotoxin burden, nutritional need, mitochondrial function and detox capability in one, easy, urine sample.
|Mold Overgrowth||Organic Acids Test:
GI tract invasive growth of metabolites of mycotoxins – aspergillus and fusarium
Toxicity can happen independently or simultaneously with growth and colonization
|Mycotoxin Potential Exposure||X – 2 metabolites metabolite indicators aspergillus and fusarium||X – 20 tests|
|Mycotoxin Toxic Burden||X|
|Mycotoxin Specific Info||X|
Please refer to your test’s specific Test Preparation and Instructions for more information regarding the potential effects of medications, foods, and supplements on this test.
You may also consult your healthcare provider prior to making any changes to your medications.
To ensure optimal results, it is recommended to ship urine specimens to the laboratory immediately after collection as they start degrading in quality soon after. In case immediate shipping is not possible, here are some guidelines for specimen stability: Urine samples can be stored in the refrigerator for up to 5 days, and for extended periods in the freezer. This applies to all urine tests performed at MosaicDX, except for the Kryptopyrrole test, for which urine must be frozen immediately and received within 24 hours of collection for accurate results.
The OAT measures 76 organic acids from one easy to collect urine sample.
See full list of markers below:
● HPHPA (Clostridia marker)
● 4-Cresol (C. difficile)
● DHPPA (beneficial bacteria)
● Homovanillic Acid (HVA)
● Vanillmandelic Acid (VMA)
● HVA/VMA Ratio
● 5-Hydroxyindoleacetic (5-HIAA)
● HVA/DOPAC Ratio
● Dihydroxyphenylacetic (DOPAC)
● Methylmalonic (Vitamin B12)
● Pyridoxic (Vitamin B6)
● Pantothenic (Vitamin B5)
● Glutaric (Vitamin B2-Riboflavin)
● Ascorbic (Vitamin C)
● (Vitamin Q10-CoQ10)
● N-Acetylcysteine (Glutathione precursor and chelating agent)
● Methylcitric (Vitamin H-Biotin)
The Organic Acids Test (OAT) is a simple and efficient way to assess a number of metabolic pathways providing insight into imbalances and nutrient needs. The OAT can provide insight into a wide range of conditions, making it valuable for individuals who are experiencing complex chronic conditions.
The OAT test report is organized into clinically useful categories including:
- Intestinal Microbial Overgrowth markers evaluate for candida activity, clostridia bacteria toxins, potential mold exposure, and imbalance in the gut microflora.
- Oxalate Metabolites provide insight into oxalate levels being generated by organisms within the system or via dietary contributions.
- Glycolytic Cycle Metabolites and Mitochondrial Markers (Krebs Cycle and Amino Acid Metabolites) evaluate for metabolic efficiency (e.g., use of glucose and amino acids for energy generation) and mitochondrial dysfunction.
- Neurotransmitter Metabolites evaluate for phenylalanine, tyrosine and tryptophan metabolism which are linked to neurotransmitter status and quinolinic acid production.
- Pyrimidine Metabolites & Ketone and Fatty Acid Oxidation markers give insight into folate status and cellular turnover, as well as mitochondrial utilization of fatty acids for energy production.
- Nutritional Markers provide insight into the sufficiency of essential vitamins, antioxidants, and metabolic pathway co-factors.
- Indicators of Detoxification assess for the presence of oxidative stress via markers of glutathione sufficiency and methylation versus transsulfuration function.
- Amino Acid Metabolites may suggest functional nutrient need or be reflective of genetic metabolic dysfunction if a consistently, persistently elevated level of a particular analyte is noted.
- The Mineral Metabolism marker provides insight into dietary intake of phosphate and can give insights into Vitamin D levels.
The OAT provides useful information about how well an individual’s metabolic pathways are functioning. Revealed imbalances may provide guidance around the underlying contributors to both symptoms and disease states – with improvement of associated symptoms and overall health when clinically addressed.
Symptoms and diseases associated with nutritional deficiencies and other metabolic imbalances:
- Autism Spectrum Disorders
- Digestive Disorders
- Gastrointestinal dysbiosis
- Insulin resistance
- Neurological Disorders
- Optimizing health
- Psychological Disorders
A consultation with a Personal Health Instructor on our team is included in the price of the MycoTOX Profile. Once your results are in, you will receive a link to schedule your consultation to review your results.
Symptoms and disease states that have been associated with mycotoxin exposure include the following:
- Cancer (e.g., Hepatic,
- Chronic Fatigue
- Cognitive Impairments
- Inflammatory Bowel
- Intestinal Permeability
- Multiple Sclerosis
- Other Mood
- Parkinson’s Disease
Mycotoxins are low molecular weight, secondary metabolites of fungal (mold) compounds which are increasingly recognized as a global health threat given their role in precipitating both acute and chronic adverse health outcomes.
Common fungi sources of mycotoxins include species such as Fusarium, Aspergillus, Penicillium, Alternaria, and Claviceps. To date nearly 400 potentially toxic mycotoxins produced by more than 100 fungi species have been identified, although research has focused on the most toxigenic in the public health, veterinary, and agricultural realms. Exposure to mycotoxins may occur through a variety of routes such as inhalation, ingestion, and dermal contact from airborne mold spores, food contamination, and water-damaged building environments.
Susceptibility to mycotoxins is influenced by a patient’s age, sex, presence of other underlying diseases and/or exposures, nutritional status, and length of exposure. While mycotoxin toxicity may present as an acute state marked by rapid onset with potential life-threatening illness, most of the negative health impacts observed in the developed (Western) world are due to chronic, low-dose exposures. These long-term exposures have been associated with a variety of systemic effects (mycotoxicoses) in both humans and animals – and most commonly manifest as nephrotoxicity, hepatotoxicity, immunosuppression, carcinogenicity, and teratogenicity.
Mycotoxins are toxic metabolites produced by certain types of molds – microscopic filamentous fungi that are pervasive in both outdoor and indoor environments. Common routes of exposure to these low-molecular weight compounds include inhalation, dermal contact, and ingestion via common contaminated food sources (corn, cereals, ground and tree nuts, spices, dried fruits, apples, coffee, meat, milk, and eggs).
Attention is increasingly being given to indoor air pollution resulting not only from the influx of irritant agents (spores, pollens) from the outdoor environment, but also from the growth of molds, fungi and bacteria on almost all indoor materials (drywall, paint, wallpaper, carpeting, etc.) when excessive moisture is present in high humidity geographic areas or water-damaged buildings. The growth of these biological agents in damp environments leads to the production of spores, cells, fragments and volatile organic compounds which have been linked to a wide range of health hazards, including exacerbation of asthma as well as allergic and infectious respiratory diseases infections.
Adverse health effects may be acute or chronic in nature, and the degree of impact can vary depending on the age, sex, genetics, and underlying health status of the exposed individual, as well as the duration and dose magnitude of the offending substance and their synergistic effects with other mycotoxins.
Because mycotoxins are byproducts of mold metabolism, clinicians assessing symptomatic patients with known mold exposure – or with an environmental history concerning for mold exposure – will also need to consider the concomitant presence of mycotoxins and their potential negative health impact as well.